Vascular biomarkers and correlation with peripheral vasculopathy in systemic sclerosis

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Chora, I (Author) FMUP; Guiducci, S (Author) Other; Manetti, M (Author) Other; Romano, E (Author) Other; Mazzotta, C (Author) Other; Bellando Randone, S (Author) Other; Ibba Manneschi, L (Author) Other; Matucci Cerinic, M (Author) Other; soares, r (Author) FMUP

Journal

Title: Autoimmunity Reviews

Vol. 14

Pages: 314-322

ISSN: 1568-9972

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 48 Citations

Scopus - 48 Citations

Other information

Authenticus ID: P-00A-6GZ

DOI: 10.1016/j.autrev.2014.12.001

Abstract (EN): Vascular disease is a hallmark of systemic sclerosis (SSc). It is present in every patient, being responsible both for the earliest clinical manifestations and the major life-threatening complications of the disease, and thus determining important morbidity and mortality. In SSc, progressive vascular injury leads to vascular tone dysfunction and reduced capillary blood flow, with consequent tissue ischemia and chronic hypoxia. These phenomena are often accompanied by abnormal levels of vascular factors. Microangiopathy in SSc may be easily assessed by nailfold videocapillaroscopy. The variety of derangements detected in the nailfold capillaries is accompanied by abnormal levels of different vascular mediators and appears to be the best evaluable predictor of the development of peripheral vascular complications, such as digital ulcers. The purpose of this review is to summarize in SSc the most relevant vascular biomarkers and the main associations between vascular biomarkers and capillaroscopic parameters and/or the presence of digital ulcers. Vascular biomarkers could become useful predictive factors of vascular damage in SSc, allowing an earlier management of vascular complications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9