In vivo demonstration of the suitability of piezoelectric stimuli for bone reparation

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Ribeiro, C (Author) Other; Correia, DM (Author) Other; Rodrigues, I (Author) Other; Guardao, L (Author) Other; Guimaraes, S (Author) Other; soares, r (Author) FMUP; Lanceros Mendez, S (Author) Other

Journal

Title: Materials Letters

Vol. 209

Pages: 118-121

ISSN: 0167-577X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 42 Citations

Scopus - 45 Citations

Other information

Authenticus ID: P-00N-4G5

DOI: 10.1016/j.matlet.2017.07.099

Abstract (EN): The potential of piezoelectric biomaterials for bone tissue engineering is demonstrated. This work proves that the use of piezoelectric poly(vinylidene fluoride) (PVDF), able to provide electrical stimuli upon mechanical solicitation to the growing cells, enhances bone regeneration in vivo. Poled and non-poled beta-PVDF films and randomly oriented electrospun fiber mats have been used to test their osteogenic properties in Wistar rats by analyzing new bone formation in vivo. After 4 weeks, defect implanted with poled beta-PVDF films demonstrated significantly more defect closure and bone remodeling, showing the large potential of piezoelectric biomaterials for bone repair.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4