Idiopathic intracranial hypertension and oxaliplatin: a causal association?

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Painhas, T (Author) Other; Amorim, M (Author) Other; soares, r (Author) FMUP; Duarte, L (Author) Other; Salgado Borges, J (Author) Other

Journal

Title: Cutaneous and Ocular Toxicology

Vol. 34

Pages: 237-241

ISSN: 1556-9527

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00G-S1Y

DOI: 10.3109/15569527.2014.944647

Abstract (EN): We report a case of a 54-year-old woman presented at the emergency service with complaints of transitory visual obscurations for four days, and headache, nausea and occasional vomiting in the last two months. She had been diagnosed of colorectal cancer one year ago and she was on treatment with oxaliplatin on a FOLFOX schedule. On ophthalmic examination, the vision was of 20/20 in both eyes and bilateral disc swelling was noted. The neurologic examination was normal. Magnetic resonance revealed no changes. A diagnostic lumbar puncture demonstrated an elevated opening pressure of 290 mm H2O with normal compounds. Due to the suspicion of ocular toxicity, oxaliplatin treatment was stopped. Treatment with oral acetazolamide was started and maintained for one month. In three weeks ocular and systemic symptoms totally disappeared and disc swelling gradually improved in the following months. Ocular toxicity has been reported as an infrequent adverse effect of oxaliplatin, but intracranial idiopathic pressure has not yet been described. Findings in this case suggest that oxaliplatin could be the cause for these symptoms. As the use of oxaliplatin is increasing as first-line treatment in colorectal cancer, we have to be alert to its potential toxicity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5