Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Baker, K (Author) Other; Raemdonck, K (Author) FMUP; Dekkak, B (Author) Other; Snelgrove, RJ (Author) Other; Ford, J (Author) Other; Shala, F (Author) Other; Belvisi, MG (Author) Other; Birrell, MA (Author) Other

Journal

Title: Respiratory Research

Vol. 17

ISSN: 1465-9921

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 23 Citations

Other information

Authenticus ID: P-00K-HAS

DOI: 10.1186/s12931-016-0384-x

Abstract (EN): Background: Asthma prevalence has increased world-wide especially in children; thus there is a need to develop new therapies that are safe and effective especially for patients with severe/refractory asthma. CD4(+) T cells are thought to play a central role in disease pathogenesis and associated symptoms. Recently, TRPV1 has been demonstrated to regulate the activation and inflammatory properties of CD4(+) cells. The aim of these experiments was to demonstrate the importance of CD4(+) T cells and the role of TRPV1 in an asthma model using a clinically ready TRPV1 inhibitor (XEN-D0501) and genetically modified (GM) animals. Methods: Mice (wild type, CD4(-/-) or TRPV1(-/-)) and rats were sensitised with antigen (HDM or OVA) and subsequently topically challenged with the same antigen. Key features associated with an allergic asthma type phenotype were measured: lung function (airway hyperreactivity [AHR] and late asthmatic response [LAR]), allergic status (IgE levels) and airway inflammation. Results: CD4(+) T cells play a central role in both disease model systems with all the asthma-like features attenuated. Targeting TRPV1 using either GM mice or a pharmacological inhibitor tended to decrease IgE levels, airway inflammation and lung function changes. Conclusion: Our data suggests the involvement of TRPV1 in allergic asthma and thus we feel this target merits further investigation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10