Longitudinal association of adiposity and high-sensitivity C-reactive protein from adolescence into early adulthood

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Cabral, M (Author) Other; Severo M (Author) FMUP; Barros H (Author) FMUP; guimaraes, jt (Author) FMUP; Ramos E (Author) FMUP

Journal

Title: Nutrition, Metabolism and Cardiovascular Diseases

Vol. 29 No. 8

Pages: 590-597

ISSN: 0939-4753

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-00Q-K76

DOI: 10.1016/j.numecd.2019.03.008

Abstract (EN): Background and aims: Longitudinal studies relating adiposity with low-grade inflammation are scarce. We aimed to examine the longitudinal association between the cumulative exposure to adiposity and low-grade inflammation from adolescence into early adulthood. Methods and results: Data from a population-based cohort (EPITeen) (n = 1147) was analyzed. Body mass index (BMI), body fat percentage (BF%), waist circumference (WC), and waist-toheight ratio (WHtR) and high-sensitivity C-reactive protein (hsCRP) were ascertained at 13, 17 and 21 years of age and standardized for each wave. Generalized least squares models with a compound symmetry correlation structure were fitted to estimate the longitudinal effect of adiposity on hsCRP and results were presented as linear regression coefficients and 95% confidence intervals [beta (95%CI)].The final model estimated the association between the difference in adiposity between two consecutive evaluations (13-17 and 17 to 21-years-old), adjusted for previous adiposity and hsCRP levels, sex, parental education, leisure-time physical activity and fruits and vegetables intake. A positive association between the cumulative exposure to adiposity and final hsCRP was observed, in which the difference between adiposity indicators of two consecutive study waves was independently associated with hsCRP: 0.382 (0.299; 0.465) for BMI, 0.234 (0.164; 0.304) for WC, 0.395 (0.314; 0.477) for BF% and 0.195 (0.133; 0.258) for WHtR. Conclusion: A significant longitudinal effect of the accumulation of adiposity on low-grade inflammation was observed. The change in adiposity from consecutive study waves was shown to have a stronger effect on final hsCRP concentrations than both previous adiposity and hsCRP levels.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8