Adverse drug reactions in adolescents: a review of reporting to a national pharmacovigilance system

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Rebelo Gomes, ER (Author) Other; Cristina Costa Santos (Author) FMUP

Journal

Title: Expert Opinion on Drug Safety

Vol. 19 No. 7

Pages: 915-922

ISSN: 1474-0338

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00S-DFP

DOI: 10.1080/14740338.2020.1771305

Abstract (EN): Objective Adverse drug reactions (ADR) cause significant morbidity, mortality and health costs and have an important prevalence in all ages. Few studies focus on ADR in adolescents. The goal of this study was to characterize a case series of ADR reported to the Portuguese Pharmacovigilance System (PPS) of the National Authority of Medicines and Health Products (INFARMED, I.P.) during an eleven-year period (from 2006 to 2016) concerning this specific population. Methods Retrospective analysis of reports concerning patients from 10 to 18 years received by the PPS between 2006 and 2016. The authors evaluated patients' demographics (age and sex). The characteristics and seriousness of the reactions, the type of reaction reported, and the drugs involved were assessed. Results The authors found 782 reports (59% females). Most reports came from physicians (61%). Overall 80% of the reports described serious ADR. A greater proportion of serious events was found among males. Most reactions referred to general disorders and administration site conditions (38%), followed by skin and subcutaneous tissue reactions (33%). In 3(rd)and 4(th)were gastrointestinal disorders (24%) and the nervous system disorders (23%), the former more frequent among females. Vaccines were the most represented group (42%) followed by antibacterials for systemic use (19%). Conclusion Major findings considering drugs involved and the reported reactions varied according to age and sex.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8