FETAL PAIN Neurobiological Causes and Consequences

• Type: Another Publication in an International Scientific Journal
• Date: 2010

Authors

Goncalves, N (Author) Other; Sandra Rebelo (Author) FMUP; Isaura Tavares (Author) FMUP

Journal

Title: Acta Medica Portuguesa

Vol. 23 No. 5

Pages: 419-426

ISSN: 0870-399X

Publisher: Ordem dos Medicos

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 5 Citations

Other information

Authenticus ID: P-003-6T5

Abstract (EN): FETAL PAIN Neurobiological Causes and Consequences The existence of putatively painful situations to the fetus demands a careful evaluation of the issue of fetal pain. Several indirect approaches are used to evaluate the existence of fetal pain. Neurobiological studies showed that from the 30(th) week on, the anatomical and physiological system for pain transmission is already developed, with the connections from the periphery to the cortex being successively established. Stress responses to a painful stimulation are complex but they can be detected from the 16(th) week on. There is activation of the hypothalamus-pituitary-adrenal axis, autonomic nervous system and hemodynamic changes in response to nociceptive stimulation. In prematures exposed to pain there are significant increases of adrenaline, noradrenaline and cortisol, hemodynamic changes, motor reflexes and facial reactions. The changes induced by strong nociceptive stimulation of newborns have important postnatal consequences since they affect future reactions to noxious stimuli. Central sensitization and immaturity of the pain inhibitory system are the main neurobiological explanations for the increased pain. Detailed studies of the neurobiological mechanisms of the transmission of painful stimuli along with follow-up studies of the consequences of exposure to pain during the development of the fetus are necessary to fully understand fetal pain.

Language: Portuguese

Type (Professor's evaluation): Scientific

No. of pages: 8