"Hotheaded": The role OF TRPV1 in brain functions

• Type: Another Publication in an International Scientific Journal
• Date: 2014

Authors

Martins, D (Author) Other; Isaura Tavares (Author) FMUP; Morgado, C (Author) Other

Journal

Title: Neuropharmacology

Vol. 85

Pages: 151-157

ISSN: 0028-3908

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 56 Citations

Scopus - 63 Citations

Other information

Authenticus ID: P-009-KCP

DOI: 10.1016/j.neuropharm.2014.05.034

Abstract (EN): The TRPV1 (vanilloid 1) channel is best known for its role in sensory transmission in the nociceptive neurons of the peripheral nervous system. Although first studied in the dorsal root ganglia as the receptor for capsaicin, TRPV1 has been recently recognized to have a broader distribution in the central nervous system, where it is likely to constitute an atypical neurotransmission system involved in several functions through modulation of both neuronal and glial activities. The endovanilloid-activated brain TRPV1 channels seem to be involved in somatosensory, motor and visceral functions. Recent studies suggested that TRPV1 channels also account for more complex functions, as addiction, anxiety, mood and cognition/learning. However, more studies are needed before the relevance of TRPV1 in brain activity can be clearly stated. This review highlights the increasing importance of TRPV1 as a regulator of brain function and discusses possible bases for the future development of new therapeutic approaches that by targeting brain TRPV1 receptors might be used for the treatment of several neurological disorders.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7