Nucleus-Cytoskeleton Crosstalk During Mitotic Entry

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Dantas, M (Author) Other; Lima, JT (Author) Other; J Ferreira (Author) FMUP

Journal

Title: Frontiers in Cell and Developmental Biology

Vol. 9

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 2 Citations

Other information

Authenticus ID: P-00T-P01

DOI: 10.3389/fcell.2021.649899

Abstract (EN): In preparation for mitosis, cells undergo extensive reorganization of the cytoskeleton and nucleus, so that chromosomes can be efficiently segregated into two daughter cells. Coordination of these cytoskeletal and nuclear events occurs through biochemical regulatory pathways, orchestrated by Cyclin-CDK activity. However, recent studies provide evidence that physical forces are also involved in the early steps of spindle assembly. Here, we will review how the crosstalk of physical forces and biochemical signals coordinates nuclear and cytoplasmic events during the G2-M transition, to ensure efficient spindle assembly and faithful chromosome segregation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9