Post-transplant Lymphoproliferative Disorder: A Single-Center Experience

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Ferreira, H (Author) Other; Bustorff, M (Author) Other; Santos, J (Author) Other; Ferreira, I (Author) Other; Sampaio, S (Author) FMUP; Salome, I (Author) Other; Bastos, J (Author) Other; Bergantim, R (Author) FMUP; Principe, F (Author) Other; Pestana M (Author) FMUP

Journal

Title: Transplantation Proceedings

Vol. 47

Pages: 981-984

ISSN: 0041-1345

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00G-5XR

DOI: 10.1016/j.transproceed.2015.03.017

Abstract (EN): Background. Post-transplant lymphoproliferative disorder (PTLD) is the second most common neoplasia after adult kidney transplantation (KT). Methods. We retrospectively analyzed 8 adult patients who underwent KT in our center, diagnosed with PTLD between 2001 and 2014. Results. Six patients were men. The median age at presentation was 43 years and the median time since transplantation was 7.3 years. Three patients had previously received anti-thymocyte globulin/OKT3, and all were taking calcineurin inhibitors (CNI) at diagnosis. The monomorphic type was the most common, with diffuse large B-cell lymphoma as the origin. The most frequent presentation was fever. Four in five patients had Epstein-Barr related PTLD. All patients received various regimens of immunosuppression reduction (IR), with 4 converting CNI to mTOR inhibitor (imTOR). Subsequent treatment (when needed) was chemotherapy, radiotherapy, and surgery. The maximum follow-up time was 6.7 years, with a 50% mortality rate that occurred at a median time of 3.5 months (2 died with functioning kidney). All 4 patients who were in remission at the end of follow-up had CNI conversion to imTOR, and none lost the allograft. Conclusions. Despite the small number of cases, our results confirm the high PTLD impact in overall and allograft survival. Our PTLD type distribution is in accord with the literature. First-line PTLD treatment is IR, but the best method is still unknown; our results may suggest a beneficial effect of CNI conversion to imTOR.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4