STADEERS - A SOFTWARE PACKAGE FOR THE STATISTICAL DESIGN OF EXPERIMENTS PERTAINING TO THE ESTIMATION OF PARAMETERS IN RATE EXPRESSIONS THAT DESCRIBE ENZYME-CATALYZED PROCESSES

• Type: Article in International Scientific Journal
• Date: 1993

Authors

BALCAO, VM (Author) Other; F. Xavier Malcata (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: COMPUTER APPLICATIONS IN THE BIOSCIENCES

Vol. 9

Pages: 629-637

ISSN: 0266-7061

Indexing

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Other information

Authenticus ID: P-001-MC6

Abstract (EN): This paper describes a computational algorithm (STADEERS-STAtistical Design of Experiments in Enzyme ReactorS) for the statistical design of biochemical engineering experiments. The type of experiment that qualifies for this package involves a batch reaction catalyzed by a soluble enzyme where the activity of the enzyme decays with time. Assuming that both the catalytic action and the deactivation of the enzyme obey known rate expressions, the present code is helpful in the process of obtaining estimates of the kinetic parameters by providing as output the times at which samples should be withdrawn from the reacting mixture. Starting D-optimal design is used as a basis for the statistical approach. This BASIC code is a powerful tool when fitting a rate expression to data because it increases the effectiveness of experimentation by helping the biochemical kineticist obtain data points with the largest possible informational content.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9