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Tissue stem cells: the new actors in the aneuploidy field

Title
Tissue stem cells: the new actors in the aneuploidy field
Type
Another Publication in an International Scientific Journal
Year
2019
Authors
Bras, R
(Author)
Other
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Sunkel, CE
(Author)
ICBAS
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Resende, LP
(Author)
Other
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Journal
Title: Cell CycleImported from Authenticus Search for Journal Publications
Vol. 18
Pages: 1813-1823
ISSN: 1538-4101
Publisher: Taylor & Francis
Indexing
Publicação em ISI Web of Knowledge ISI Web of Knowledge - 0 Citations
Publicação em Scopus Scopus - 0 Citations
Other information
Authenticus ID: P-00Q-WDD
Abstract (EN): The development of multicellular organisms and the maintenance of its tissues relies on mitosis. However, this process represents a major challenge for genomic stability as each time a cell division occurs there are multiple steps where errors can lead to an abnormal chromosomal content in daughter cells - aneuploidy. Aneuploidy was first postulated to act as a tumour promoting agent over one century ago. Since then, we have learned to appreciate the complexity involving the cellular responses to aneuploidy and to value the importance of models where aneuploidy is induced in vivo and in a cell-type specific manner. Recent data suggests that stem cells evolved a distinct response to aneuploidy, being able to survive and proliferate as aneuploid. Since stem cells are the main cells responsible for tissue renewal, it is of the utmost importance to place the spotlight on stem cells within the aneuploidy field. Here, we briefly review some of the biological mechanisms implicated in aneuploidy, the relationship between aneuploidy and tissue pathologies, and summarize the most recent findings in Drosophila on how tissue stem cells respond to aneuploidy. Once we understand how stem cell behavior is impacted by aneuploidy, we might be able to better describe the complicated link between aneuploidy and tumourigenesis.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 11
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