Preliminary studies of microencapsulation and anticancer activity of polyphenols extract from Punica granatum peels

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Fathi, F (Author) Other; Ebrahimi, SN (Author) Other; David M Pereira (Author) FFUP; Berta Nogueiro Estevinho (Author) FEUP; Rocha, F (Author) Other

Journal

Title: Canadian Journal of Chemical Engineering

ISSN: 0008-4034

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Associated Projects

MicroDelivery - Desenvolvimento de sistemas funcionais de libertação controlada por microencapsulação de compostos ativos e naturais, com interesse terapêutico, nutricional e tecnológico

Other information

Authenticus ID: P-00W-0Z6

DOI: 10.1002/cjce.24348

Abstract (EN): The purpose of this study was to prepare functional formulations using two different types of Punica granatum (pomegranate) peels extracts (the native and the enriched extract), as an important source of polyphenolic compounds such as punicalagin and ellagic acid. These two extracts were microencapsulated by a spray-drying technique. Polyphenol constituents of P. granatum play a significant role in the prevention of different diseases from cancer to cardiovascular and neurodegenerative diseases. In general, polyphenols are sensitive and present low bioavailability in the human body. Microencapsulation could be a perfect alternative to modify the reactivity, durability, sensitivity, and photosensitivity of these natural compounds. Arabic gum, pectin, and modified chitosan were used as biopolymers-based carriers in this research. The mean size of the microparticles prepared is between 2.55-6.86 mu m (volume distribution). Release studies were implemented. The fastest release was observed for Arabic gum-based carriers. The pectin-based microparticles showed the slowest release profile. The Korsmeyer-Peppas model was adjusted to the experimental release profiles. In addition, some anticancer activity studies were performed. When incubated with the human gastric cancer cell line AGS and human lung cancer cell line A549, both extracts elicited some loss of cancer cell viability, which increased in the case of the enriched extract. The bioactive pomegranate extracts microencapsulated seem to be a valid strategy to enhance their biological activity. A final powder formulation was obtained, which can improve the bioavailability and stability of these active constituents and overcome their limitations of application.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13