Rapid Assessment of Blood Pressure Variability and Outcome After Successful Thrombectomy

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Castro, P (Author) Other; Ferreira, F (Author) Other; Nguyen, CK (Author) Other; Payabvash, S (Author) Other; Tan, CO (Author) Other; Sorond, F (Author) Other; Elsa Azevedo (Author) FMUP; Petersen, N (Author) Other

Journal

Title: Stroke

Vol. 52

Pages: E531-E535

ISSN: 0039-2499

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-00V-BY2

DOI: 10.1161/strokeaha.121.034291

Abstract (EN): Background and Purpose: High blood pressure (BP) variability after endovascular stroke therapy is associated with poor outcome. Conventional BP variability measures require long recordings, limiting their utility as a risk assessment tool to guide clinical decision-making. Here, we performed rapid assessment of BP variability by spectral analysis and evaluated its association with early clinical improvement and long-term functional outcomes. Methods: We conducted a prospective study of 146 patients with anterior circulation ischemic stroke who underwent successful endovascular stroke therapy. Spectral analysis of 5-minute recordings of beat-to-beat BP was used to quantify BP variability. Outcomes included initial clinical response and modified Rankin Scale at 90 days. Results: Increased BP variability at high frequencies was independently associated with poor functional outcome at 90 days (adjusted odds ratio [aOR], 1.85 [95% CI, 1.07-3.25], P=0.03; low-/high-frequency ratio aOR, 0.67 [95% CI, 0.46-0.92], P=0.02) and reduced likelihood of an early neurological recovery (aOR, 0.62 [95% CI, 0.44-0.91], P=0.01 and aOR, 1.37 [95% CI, 1.03-1.87], P=0.04, respectively). Conclusions: High-frequency BP oscillations after successful reperfusion may be harmful and associate with a decreased likelihood of neurological recovery and favorable functional outcomes. Rapid assessment of BP variability throughout the postreperfusion period is feasible and may allow for a more personalized BP management.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5