SALTIRE-RAAVE: targeting calcific aortic valve disease LDL-density-radius theory

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Rajamannan, NM (Author) Other; Greve, AM (Author) Other; Moura LM (Author) FMUP; Best, P (Author) Other; Wachtell, K (Author) Other

Journal

Title: Expert Review of Anti-Infective Therapy

Vol. 13

Pages: 355-367

ISSN: 1478-7210

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00A-9J3

DOI: 10.1586/14779072.2015.1025058

Abstract (EN): SALTIRE and RAAVE were the first two studies to evaluate the use of statin therapy for impeding calcific aortic valve disease (CAVD). This review presents the findings of low-density lipoprotein (LDL)-density-radius theory as tested using the combined results from the SALTIRE and RAAVE studies. Patients who received statin therapy had a greater degree of LDL cholesterol lowering, seen as the % change in LDL (47 vs 2%, p = 0.012), which in itself was significantly associated with a lesser change in aortic valve area (AVA; p < 0.001 and R-2 = 0.27). The percent change in the AVA for the treated patients was 5% and 15% for the nontreated patients (p = 0.579 and R-2 = 0.03). In summary, these published findings suggest that when applying the LDL-density-radius theory, which combines the cellular biology and the hemodynamics as defined by the continuity equation for AVA, there may be a role for lipid-lowering therapy in contemporary patients with calcific aortic valve disease (CAVD).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13