Ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal hirsute woman [Deficiência de 21-hidroxilase ovariana intratumoral na virilização da mulher pós-menopausa]

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Souto, SB (Author) Other; Baptista, PV (Author) Other; Barreto, F (Author) Other; Sousa, PF (Author) Other; Braga, DC (Author) Other; Carvalho, Davide (Author) FMUP

Journal

Title: Arquivos Brasileiros de Endocrinologia e Metabologia

Vol. 56

Pages: 672-676

ISSN: 0004-2730

Publisher: Universidade de São Paulo

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-008-8T9

DOI: 10.1590/s0004-27302012000900012

Abstract (EN): Virilising ovarian tumours are a rare cause of hyperandrogenism in women, accounting for less than 5% of all ovarian neoplasms. It occurs most often in - and postmenopausal women. We report a case of a 64 year-old woman with signs of virilisation that had started 3 years before. Blood hormone analysis revealed increased levels of testosterone, and 17-hydroxyprogesterone. The tetracosactin test revealed 21-hydroxylase deficiency. Radiological imaging demonstrated a nodule in her left ovary. The patient was submitted to bilateral laparoscopic oophorectomy, and histopathological examination revealed a luteoma of the left ovary. Postoperative serum testosterone level and 17-hydroxyprogesterone returned to normal levels in one month. Virilism regressed within six months. Our patient also showed an elevation in 17-OHP serum levels. Normalization of 17-OHP after oophorectomy suggests a case of intratumoral 21-hydroxylase deficiency. To our knowledge, this is the first description of ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal woman. © ABE&M todos os direitos reservados.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5