Diagnostic tests for Cushing's syndrome differ from published guidelines: Data from ERCUSYN

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Valassi, E (Author) Other; Franz, H (Author) Other; Brue, T (Author) Other; Feelders, RA (Author) Other; Netea Maier, R (Author) Other; Tsagarakis, S (Author) Other; Webb, SM (Author) Other; Yaneva, M (Author) Other; Reincke, M (Author) Other; Droste, M (Author) Other; Komerdus, I (Author) Other; Maiter, D (Author) Other; Kastelan, D (Author) Other; Chanson, P (Author) Other; Pfeifer, M (Author) Other; Strasburger, CJ (Author) Other; Tóth, M (Author) Other; Chabre, O (Author) Other; Tabarin, A (Author) Other; Krsek, M (Author) Other; Fajardo, C (Author) Other; Bolanowski, M (Author) Other; Santos, A (Author) Other; Wass, JAH (Author) Other; Trainer, PJ (Author) Other; Ambrogio, A (Author) Other; Aranda, G (Author) Other; Arosio, M (Author) Other; Balomenaki, M (Author) Other; Beck Peccoz, P (Author) Other; Berr Kirmair, C (Author) Other; Bollerslev, J (Author) Other; Carvalho, Davide (Author) FMUP; Cavagnini, F (Author) Other; Christ, E (Author) Other; Demtröder, F (Author) Other; Denes, J (Author) Other; Dimopoulou, C (Author) Other; Dreval, A (Author) Other; Dusek, T (Author) Other; Erdinc, E (Author) Other; Evang, JA (Author) Other; Fazel, J (Author) Other; Fica, S (Author) Other; Ghigo, E (Author) Other; Goth, M (Author) Other; Greenman, Y (Author) Other; Greisa, V (Author) Other; Halperin, I (Author) Other; Hanzu, FA (Author) Other; Hermus, A (Author) Other; Johannsson, G (Author) Other; Kamenicky, P (Author) Other; Kasperlik Zaluska, A (Author) Other; Kirchner, J (Author) Other; Kraljevic, I (Author) Other; Kruszynska, A (Author) Other; Lambrescu, I (Author) Other; Lang, S (Author) Other; Luger, A (Author) Other; Marpole, N (Author) Other; Martin, S (Author) Other; Martinie, M (Author) Other; Moros, O (Author) Other; Newell Price, J (Author) Other; Orbetzova, M (Author) Other; Paiva, I (Author) Other; Giraldi, FP (Author) Other; Pereira, AM (Author) Other; Pickel, J (Author) Other; Pirags, V (Author) Other; Ragnarsson, O (Author) Other; Reghina, AD (Author) Other; Riesgo, P (Author) Other; Roberts, M (Author) Other; Roerink, S (Author) Other; Roig, O (Author) Other; Rowan, C (Author) Other; Rudenko, P (Author) Other; Sahnoun, MA (Author) Other; Salvador, J (Author) Other; Sigurjonsdottir, HA (Author) Other; Polovina, TS (Author) Other; Smith, R (Author) Other; Stachowska, B (Author) Other; Stalla, G (Author) Other; Tóke, J (Author) Other; Ubina, E (Author) Other; Vinay, S (Author) Other; Wagenmakers, M (Author) Other; Werner, S (Author) Other; Young, J (Author) Other; Zdunowski, P (Author) Other; Zopf, K (Author) Other; Zopp, S (Author) Other; Zosin, I (Author) Other

Journal

Title: European Journal of Endocrinology

Vol. 176

Pages: 613-624

ISSN: 0804-4643

Publisher: BioScientifica Ltd.

Indexing

Scopus - 29 Citations

Other information

Authenticus ID: P-00R-0JN

DOI: 10.1530/eje-16-0967

Abstract (EN): Objective: To evaluate which tests are performed to diagnose hypercortisolism in patients included in the European Registry on Cushing's syndrome (ERCUSYN), and to examine if their use differs from the current guidelines. Patients and methods: We analyzed data on the diagnostic tests performed in 1341 patients with Cushing's syndrome (CS) who have been entered into the ERCUSYN database between January 1, 2000 and January 31, 2016 from 57 centers in 26 European countries. Sixty-seven percent had pituitary-dependent CS (PIT-CS), 24% had adrenaldependent CS (ADR-CS), 6% had CS from an ectopic source (ECT-CS) and 3% were classified as having CS from other causes (OTH-CS). Results: Of the first-line tests, urinary free cortisol (UFC) test was performed in 78% of patients, overnight 1 mg dexamethasone suppression test (DST) in 60% and late-night salivary cortisol (LSaC) in 25%. Use of LSaC increased in the last five years as compared with previous years (P < 0.01). Use of HDDST was slightly more frequent in the last 5 years as compared with previous years (P < 0.05). Of the additional tests, late-night serum cortisol (LSeC) was measured in 62% and 48-h 2 mg/day low-dose dexamethasone suppression test (LDDST) in 33% of cases. ACTH was performed in 78% of patients. LSeC and overnight 1 mg DST supported the diagnosis of both PIT-CS and ADR-CS more frequently than UFC (P < 0.05). © 2017 European Society of Endocrinology Printed in Great Britain.

Language: English

Type (Professor's evaluation): Scientific