Predictors of the effectiveness of insulin pumps in patients with type 1 diabetes mellitus

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Neves, JC (Author) Other; Neves, JS (Author) FMUP; Neves, C (Author) Other; Carvalho, Davide (Author) FMUP

Journal

Title: Endocrine

ISSN: 0969-711X

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-890

DOI: 10.1007/s12020-021-02837-4

Abstract (EN): Purpose Insulin pump therapy has become the preferential treatment for type 1 diabetes (T1D) as it mimics the physiological secretion of insulin better than multiple daily injections. However, not all patients improve with insulin pump therapy. This study aims to determine the predictors of the effectiveness of insulin pumps in T1D. Methods We conducted a retrospective observational study of patients who started insulin pumps. Data from four timepoints (before, at 6, 12, and 36 months) were evaluated for outcomes of glycemic control and safety. The association of baseline predictors with outcomes was analyzed using linear and logistic regression models. Results We evaluated 136 patients (57.4% females, age 36 +/- 12 years, duration of T1D 14 +/- 9 years). During the follow-up, there was a mean decrease of HbA1c of 0.9 +/- 1.2%. The improvement in HbA1c was independent of sex, age, and duration of T1D. Higher baseline HbA1c, family history of diabetes, and not being treated with statins were predictors of improvement in HbA1c. Not being treated with statins and higher baseline HbA1c predicted improvement in HbA1c without worsening hypoglycemia. History of hypoglycemia was a predictor of severe hypoglycemia. Family history, higher baseline HbA1c, and psychological/psychiatric disorders were predictors of ketoacidosis. Conclusion Benefits of insulin pump were independent of sex, age, and duration of T1D. Baseline HbA1c, family history of diabetes, treatment with statins, history of hypoglycemia, and psychological/psychiatric disorders were predictors of outcomes, and may allow the identification of patients who benefit most from insulin pump therapy or who are at increased risk of complications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10