The Impact of Bariatric Surgery on Hepatic Function and Predictors of Liver Steatosis and Fibrosis

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Borges Canha, M (Author) FMUP; Neves, JS (Author) FMUP; Mendonca, F (Author) Other; Silva, MM (Author) Other; Costa, C (Author) Other; Cabral, PM (Author) Other; Guerreiro, V (Author) Other; Lourenco, R (Author) Other; Meira, P (Author) Other; Salazar, D (Author) Other; Ferreira, MJ (Author) Other; Pedro, J (Author) Other; Leite, A (Author) Other; Viana, S (Author) Other; Sande, A (Author) Other; Belo, S (Author) Other; Lau, E (Author) FMUP; Freitas, P (Author) FMUP; Carvalho, Davide (Author) FMUP

Journal

Title: Obesity Surgery

Vol. 30

Pages: 2935-2941

ISSN: 0960-8923

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-00S-1WQ

DOI: 10.1007/s11695-020-04622-0

Abstract (EN): Purpose To evaluate the variation in parameters of hepatic function and in the scores Fatty Liver Index (FLI; predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis), 1 year after bariatric surgery. Material and Methods This is a observational retrospective cohort study in patients with morbid obesity that underwent bariatric surgery in our centre. We used two linear regression models: (1) unadjusted and (2) adjusted for surgery type, sex, age, body mass index, diabetes, and dyslipidaemia. Results The included population (n = 1955) had an average age of 43.1 +/- 10 years and 85.8% were female. Diabetes was present in 32.4% of the patients, 45.1% had dyslipidaemia, and 62.2% had hypertension. Twelve percent were submitted to gastric band, 29.6% to sleeve gastrectomy, and 58.4% to gastric bypass. We observed a relevant decrease in transaminases and gamma-glutamyltransferase, and an increase in alkaline phosphatase and total bilirubin. Both FLI and BARD markedly decrease 1 year after surgery (p < 0.01). Comparing the surgical procedures, sleeve gastrectomy was associated with a greater reduction of hepatic enzymes and of both FLI and BARD compared with gastric band. Comparing with gastric bypass, sleeve was associated with a greater reduction of transaminases and alkaline phosphatase, but a smaller reduction of FLI and BARD. Conclusion Bariatric surgery is associated with a reduction of the hepatic enzymes and an improvement of FLI and BARD. It may represent an effective therapeutic approach for NAFLD.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7