HIV-Infected Patients With and Without Lipodystrophy Under Combined Antiretroviral Therapy: Evaluation of Body Composition

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Grenha, I (Author) Other; Oliveira, J (Author) Other; Lau, E (Author) Other; Santos AC (Author) FMUP; Sarmento A (Author) FMUP; Pereira, J (Author) Other; Carvalho, Davide (Author) FMUP; Freitas, P (Author) FMUP

Journal

Title: Journal of Clinical Densitometry

Vol. 21

Pages: 75-82

ISSN: 1094-6950

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00N-ES2

DOI: 10.1016/j.jocd.2016.07.010

Abstract (EN): In HIV-infected patients, combined antiretroviral therapy (cART) is associated to adipose tissue redistribution known as lipodystrophy and associated cardiometabolic risk. This study aimed to evaluate the evolution of body composition in HIV-infected patients, with and without lipodystrophy, over 2 yr. We evaluated anthropometric parameters and body composition by whole-body dual-energy X-ray absorptiometry in 144 HIV-infected patients on cART. We defined lipodystrophy by fat mass ratio. Lipodystrophy was present in 45.77% of the patients. These patients presented higher HIV infection duration, cART duration, and CD4+ cell count, with no differences regarding gender, age, body mass index, and viral load. Patients with lipodystrophy showed an increase in total fat mass (9.9%) and upper-limbs fat mass (17.6%), with a decrease in total, trunk, and lower-limbs fat-free mass (2.2%; 2.2%, and 3.9%, respectively), over 2 yr. In patients without lipodystrophy, the trunk fat-free mass decreased 1.9% over time, and no changes were observed in the other studied parameters. In patients with lipodystrophy, there was predominantly a central fat mass gain, with no changes in lower limbs, suggesting that peripheral adipocytes lose their regenerative capacity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8