Thyroid Function and the Risk of Non-Alcoholic Fatty Liver Disease in Morbid Obesity

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Borges Canha, M (Author) FMUP; Neves, JS (Author) FMUP; Mendonca, F (Author) Other; Silva, MM (Author) Other; Costa, C (Author) Other; Cabral, PM (Author) Other; Guerreiro, V (Author) Other; Lourenco, R (Author) Other; Meira, P (Author) Other; Salazar, D (Author) Other; Ferreira, MJ (Author) Other; Pedro, J (Author) Other; Leite, A (Author) Other; Von Hafe, M (Author) Other; Vale, C (Author) FMUP; Viana, S (Author) Other; Sande, A (Author) Other; Belo, S (Author) Other; Lau, E (Author) Other; Freitas, P (Author) FMUP; Carvalho, Davide (Author) FMUP

Journal

Title: Frontiers In Endocrinology

Vol. 11

ISSN: 1664-2392

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-00T-0JZ

DOI: 10.3389/fendo.2020.572128

Abstract (EN): Background An association between hypothyroidism and the risk of Non-alcoholic Fatty Liver Disease (NAFLD) has been suggested. This association remains to be elucidated in patients with morbid obesity. Aim To evaluate the association between thyroid function and parameters of liver function and hepatic scores in patients with morbid obesity. Methods Patients with morbid obesity followed in our center between January 2010 and July 2018 were included. The ones without evaluation of liver and thyroid functions were excluded. Fatty Liver Index (FLI) and BARD scores were used as predictors of hepatic steatosis and fibrosis, respectively. Results We observed a positive association between TSH and both BARD (OR 1.14; p = 0.035) and FLI (OR 1.19; p = 0.010) in the unadjusted analysis. We found a negative association between free triiodothyronine levels and BARD (OR 0.70; p<0.01) and a positive association between free triiodothyronine levels and FLI (OR 1.48; p = 0.022). Concerning liver function, we found a positive association between total bilirubin and free thyroxine levels (beta = 0.18 [0.02 to 0.35]; p = 0.033) and a negative association between total bilirubin and free triiodothyronine levels (beta = -0.07 [-0.14 to -0.002]; p = 0.042). Conclusion Higher levels of TSH and free triiodothyronine may be associated with a higher risk of NAFLD, particularly steatosis, in patients with morbid obesity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7