IL-4 and IL-6 levels and adipose tissue distribution in HIV-1 patients under antiretroviral therapy

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Belo, S (Author) Other; Santos, AC (Author) Other; Madureira, A (Author) Other; Pereira, J (Author) Other; Sarmento A (Author) FMUP; Carvalho, Davide (Author) FMUP; Freitas, P (Author) FMUP

Journal

Title: Journal of Endocrinological Investigation

Vol. 38

Pages: 779-784

ISSN: 0391-4097

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00G-BGA

DOI: 10.1007/s40618-015-0256-0

Abstract (EN): Purpose Combined antiretroviral therapy (cART) for the treatment of HIV-1 infection has been associated with complications, including lipodystrophy. Several interleukins have been implicated in the pathology and physiology of lipodystrophy. The present study aimed to compare the levels of IL-4 and IL-6 in HIV-1 patients under cART with and without, clinically and fat mass ratio defined, lipodystrophy and in four different groups of fat distribution: (1) no lipodystrophy; (2) isolated central fat accumulation; (3) isolated lipoatrophy and (4) mixed forms of lipodystrophy. Methods In the present cross-sectional study we evaluated IL-4 and IL-6 levels, insulin resistance and insulin sensitivity indexes in 86 HIV-infected adults under cART. Results No significant differences in IL-4 and IL-6 levels between the four groups of body composition were observed. Patients with HOMA-IR >4 presented higher levels of IL-6 and lower levels of IL-4, although without statistical significance. No correlation between IL-6, or IL-4, HOMA-IR and quantitative body fat mass distribution was found. Conclusion Although there was a tendency for patients with isolated lipoatrophy and isolated fat accumulation to present higher IL-6 levels, these differences were not statistically significant. No differences were found relating IL-4 levels.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6