Gut Microbiota: Association with NAFLD and Metabolic Disturbances

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Lau, E (Author) Other; Carvalho, Davide (Author) FMUP; Freitas, P (Author) FMUP

Journal

Title: BioMed Research International

Vol. 2015 No. ID 531789

Pages: 1-9

ISSN: 2314-6133

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 45 Citations

Scopus - 48 Citations

Other information

Authenticus ID: P-00G-BB0

DOI: 10.1155/2015/979515

Abstract (EN): Nonalcoholic fatty liver disease is the hepatic expression of metabolic syndrome, being frequently associated with obesity, insulin resistance, and dyslipidemia. Recent lines of evidence have demonstrated a role of gut microbiota in insulin resistance, obesity, and associated metabolic disturbances, raising the interest in its relationship with NAFLD pathogenesis. Therefore, intestinal microbiota has emerged as a potential factor involved in NAFLD, through different pathways, including its influence in energy storage, lipid and choline metabolism, ethanol production, immune balance, and inflammation. The main objective of this review is to address the pathogenic association of gut microbiota to NAFLD. This comprehension may allow the development of integrated strategies to modulate intestinal microbiota in order to treat NAFLD.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9