Long term outer retinal changes in central serous chorioretinopathy submitted to half-dose photodynamic therapy

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Torres Costa, S (Author) Other; Penas, S (Author) FMUP; Cerqueira, AR (Author) Other; Brandao, E (Author) Other; Ângela Carneiro (Author) FMUP; Rocha-Sousa A (Author) FMUP; Falcão-Reis F (Author) FMUP

Journal

Title: Photodiagnosis and Photodynamic Therapy

Vol. 34

ISSN: 1572-1000

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00T-YMC

DOI: 10.1016/j.pdpdt.2021.102235

Abstract (EN): Purpose: To evaluate long-term changes in the foveal and parafoveal outer retina after half-dose photodynamic therapy (HD-PDT) in central serous chorioretinopathy (CSC). Methods: Retrospective study including CSC patients submitted to HD-PDT. Best corrected visual acuity (BCVA) was evaluated. Spectral-domain optical coherence tomography automatic segmentation algorithm was used and data on retinal, inner retinal, outer retinal and outer nuclear layers (ONL) in both foveal 1 mm (C) and parafoveal 3 mm ETDRS circles for the superior, nasal, inferior and temporal sectors, were obtained at baseline and 3, 12 and 24 months post-treatment. Subfoveal choroidal thickness, photoreceptors' outer segment thickness, subretinal fluid (SRF) height and width were also measured. Results: Twenty-one eyes of 15 patients were included. At baseline, the mean ONL thickness in the foveal area was significantly thinner in affected eyes compared to their fellow unaffected ones (55,50 +/- 32,75 mu m vs 93,00 +/- 17,0 mu m; p = 0,011), and was negatively correlated to logMAR BCVA (R=-0,601, p = 0,008) ONL thickness increased by 10,94 +/- 11,88 mu m at 24 months in the foveal area, and all the parafoveal sectors presented a similar increase. Baseline SRF width was significantly correlated with baseline BCVA (R1 = 0,483, p = 0,036), and with ONL thickness in all sectors. Conclusion: In our study we found a significant long-term increase in foveal and parafoveal ONL thickness in CSC after HD-PDT, suggesting that this seems to be a safe treatment for the outer retina. This is the first study mapping the outer retinal changes in the macular area to 24 months follow up.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7