The Red Seaweed Grateloupia turuturu Prevents Epidermal Dysplasia in HPV16-Transgenic Mice

• Type: Article in International Scientific Journal
• Date: 2021

Authors

José Almeida (Author) Other; Tiago Ferreira (Author) Other; Susana Santos (Author) Other; Maria J. Pires (Author) Other; Rui M. Gil da Costa (Author) Other; Rui Medeiros (Author) Other; Margarida M. S. M. Bastos (Author) FEUP; Maria J. Neuparth (Author) Other; Ana I. Faustino Rocha (Author) Other; Helena Abreu (Author) Other; Rui Pereira (Author) Other; Mário Pacheco (Author) Other; Isabel Gaivão (Author) Other; Eduardo Rosa (Author) Other; Paula A. Oliveira (Author) Other

Journal

Title: Nutrients

Vol. 17

Pages: 1-4529

ISSN: 2072-6643

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00V-WAK

DOI: 10.3390/nu13124529

Abstract (EN): The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed Grateloupia turuturu has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of G. turuturu against cutaneous pre-malignant lesions in transgenic mice for the human papillomavirus type 16 (HPV16). Forty-four female HPV+/- or HPV-/- mice received a standard diet or were supplemented with 10% G. turuturu for 22 consecutive days. Cutaneous lesions (ear and chest skin) were identified histologically. Complementarily, the weights and histology of internal organs as well as blood biochemical and DNA integrity parameters were also assessed. G. turuturu consistently reduced the incidence of epidermal dysplasia induced by HPV16 on both cutaneous sites. Moreover, biochemical, DNA integrity and histological analyses confirmed G. turuturu edibility as no signs of toxicity were found. Dietary supplementation with G. turuturu is an effective and safe chemopreventive strategy in this model.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11