Development and validation of combined symptom-medication scores for allergic rhinitis*

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Sousa Pinto, B (Author) FMUP; Azevedo L (Author) FMUP; Jutel, M (Author) Other; Agache, I (Author) Other; Canonica, GW (Author) Other; Czarlewski, W (Author) Other; Papadopoulos, NG (Author) Other; Bergmann, KC (Author) Other; Devillier, P (Author) Other; Laune, D (Author) Other; Klimek, L (Author) Other; Anto, A (Author) Other; Anto, JM (Author) Other; Eklund, P (Author) Other; Almeida, R (Author) FMUP; Bedbrook, A (Author) Other; Bosnic Anticevich, S (Author) Other; Brough, HA (Author) Other; Brussino, L (Author) Other; Cardona, V (Author) Other; Casale, T (Author) Other; Cecchi, L (Author) Other; Charpin, D (Author) Other; Chivato, T (Author) Other; Costa, E (Author) FFUP; Cruz, AA (Author) Other; Dramburg, S (Author) Other; Durham, SR (Author) Other; De Feo, G (Author) Other; van Wijk, RG (Author) Other; Fokkens, WJ (Author) Other; Gemicioglu, B (Author) Other; Haahtela, T (Author) Other; Illario, M (Author) Other; Ivancevich, JC (Author) Other; Kvedariene, V (Author) Other; Kuna, P (Author) Other; Larenas Linnemann, DE (Author) Other; Makris, M (Author) Other; Mathieu Dupas, E (Author) Other; Melen, E (Author) Other; Morais Almeida, M (Author) Other; Mosges, R (Author) Other; Mullol, J (Author) Other; Nadeau, KC (Author) Other; Nhan, PH (Author) Other; O'Hehir, R (Author) Other; Regateiro, FS (Author) Other; Reitsma, S (Author) Other; Samolinski, B (Author) Other; Sheikh, A (Author) Other; Stellato, C (Author) Other; Todo Bom, A (Author) Other; Tomazic, PV (Author) Other; Toppila Salmi, S (Author) Other; Valero, A (Author) Other; Valiulis, A (Author) Other; Ventura, MT (Author) Other; Wallace, D (Author) Other; Waserman, S (Author) Other; Yorgancioglu, A (Author) Other; Vries, G (Author) Other; Eerd, M (Author) Other; Zieglmayer, P (Author) Other; Zuberbier, T (Author) Other; Pfaar, O (Author) Other; Fonseca, J (Author) FMUP; Bousquet, J (Author) Other

Journal

Title: Allergy: European Journal of Allergy and Clinical Immunology

Vol. 77

Pages: 2147-2162

ISSN: 0105-4538

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 51 Citations

Scopus - 52 Citations

Other information

Authenticus ID: P-00V-WB4

DOI: 10.1111/all.15199

Abstract (EN): Background Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air(R) app to generate and validate hypothesis- and data-driven CSMSs. Methods We used MASK-air(R) data to assess the concurrent validity, test-retest reliability and responsiveness of one hypothesis-driven CSMS (modified CSMS: mCSMS), one mixed hypothesis- and data-driven score (mixed score), and several data-driven CSMSs. The latter were generated with MASK-air(R) data following cluster analysis and regression models or factor analysis. These CSMSs were compared with scales measuring (i) the impact of rhinitis on work productivity (visual analogue scale [VAS] of work of MASK-air(R), and Work Productivity and Activity Impairment: Allergy Specific [WPAI-AS]), (ii) quality-of-life (EQ-5D VAS) and (iii) control of allergic diseases (Control of Allergic Rhinitis and Asthma Test [CARAT]). Results We assessed 317,176 days of MASK-air(R) use from 17,780 users aged 16-90 years, in 25 countries. The mCSMS and the factor analyses-based CSMSs displayed poorer validity and responsiveness compared to the remaining CSMSs. The latter displayed moderate-to-strong correlations with the tested comparators, high test-retest reliability and moderate-to-large responsiveness. Among data-driven CSMSs, a better performance was observed for cluster analyses-based CSMSs. High accuracy (capacity of discriminating different levels of rhinitis control) was observed for the latter (AUC-ROC = 0.904) and for the mixed CSMS (AUC-ROC = 0.820). Conclusion The mixed CSMS and the cluster-based CSMSs presented medium-high validity, reliability and accuracy, rendering them as candidates for primary endpoints in future rhinitis trials.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16