Efficacy and safety of intravitreal and periocular injection of corticosteroids in noninfectious uveitis: a systematic review

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Jose Vieira, R (Author) FMUP; Ferreira, A (Author) Other; Meneres, P (Author) Other; Sousa Pinto, B (Author) FMUP; Figueira, L (Author) FMUP

Journal

Title: Survey of Ophthalmology

Vol. 67

Pages: 991-1013

ISSN: 0039-6257

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-00V-SZT

DOI: 10.1016/j.survophthal.2021.12.002

Abstract (EN): Uveitis is among the leading causes of visual loss in the working age population. In noninfectious uveitis, corticosteroids are the first line therapy. We sought to review systematically the evidence regarding the regional corticosteroid delivery modalities in the treatment of noninfectious uveitis. A 5-database search (Pubmed, ISI Web of Science, Cochrane, ClinicalTrials.gov, and Scopus) was performed from inception to February, 2021. Nineteen studies with a total of 1,935 eyes of 1,753 patients were selected from 8,922 abstracts retrieved by the initial search. The most frequently compared regimens were intravitreal triamcinolone acetonide injection and orbital floor triamcinolone acetonide injection (2 studies), intravitreal triamcinolone acetonide injection and posterior sub-Tenon triamcinolone acetonide injection (2 studies), and posterior sub-Tenon triamcinolone acetonide injection with the intravitreal dexamethasone implant (2 studies). Our results show that the intravitreal injec tion of corticosteroids is more effective, but is associated with more adverse events, than periocular injection. Some evidence supports the use of subconjunctival triamcinolone ace-tonide over intravitreal/periocular triamcinolone acetonide. Moreover, the overall results of 0.59 mg dosage of the intravitreal fluocinolone acetonide implant were superior to those from the 2.1 mg dose. The evidence, however, is not robust, and further studies with stan-dardized outcomes are warranted.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 23