CHOROIDAL INVOLVEMENT IN HEREDITARY TRANSTHYRETIN AMYLOIDOSIS PATIENTS

• Type: Article in International Scientific Journal
• Date: 2022-12-15

Authors

Marta, A (Author) ICBAS; Marques, JH (Author) Other; André Ferreira (Author) FMUP; Coelho, J (Author) Other; Beirão, JM (Author) ICBAS

Journal

Title: Retina

Vol. 42

Pages: 775-781

ISSN: 0275-004X

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00V-WB0

DOI: 10.1097/iae.0000000000003378

Abstract (EN): Purpose: To compare the choroidal characteristics between the eyes of patients with and without hereditary transthyretin amyloidosis. Methods: Case-control observational study with choroidal thickness and vasculature evaluation by optical coherence tomography with enhanced depth imaging protocol of the macula. Results: The study included 332 eyes: 166 eyes of hereditary transthyretin amyloidosis patients and 166 eyes of healthy patients. Mean age was similar between groups (P = 0.979). For hereditary transthyretin amyloidosis patients, on average, in all sectors analyzed (in the full 5 mm-width image [G] and also in 1-mm-width central [C], nasal [N], and temporal [T] sectors), there was a higher stromal area, a lower choroidal thickness, and a lower choroidal vascularity index, compared with the control group. The linear mixed models revealed no differences according to the systemic treatment groups. Conclusion: Hereditary transthyretin amyloidosis patients showed statistically significant differences in choroidal characteristics, compared with eyes without pathology. These age-related and statistically significant changes compared with the healthy eyes may help in the future to better monitor the systemic hereditary transthyretin amyloidosis disease and complement other systemic evaluations, including on clinical trials to analyze more objectively, the results of new therapies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7