Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Silva, AC (Author) Other; Pereira, C (Author) Other; Fonseca, ACRG (Author) Other; Pinto do O, P (Author) Other; Nascimento, DS (Author) ICBAS

Journal

Title: Frontiers in Cell and Developmental Biology

Vol. 8

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00T-EAC

DOI: 10.3389/fcell.2020.621644

Abstract (EN): The extracellular matrix (ECM) is an essential component of the heart that imparts fundamental cellular processes during organ development and homeostasis. Most cardiovascular diseases involve severe remodeling of the ECM, culminating in the formation of fibrotic tissue that is deleterious to organ function. Treatment schemes effective at managing fibrosis and promoting physiological ECM repair are not yet in reach. Of note, the composition of the cardiac ECM changes significantly in a short period after birth, concurrent with the loss of the regenerative capacity of the heart. This highlights the importance of understanding ECM composition and function headed for the development of more efficient therapies. In this review, we explore the impact of ECM alterations, throughout heart ontogeny and disease, on cardiac cells and debate available approaches to deeper insights on cell-ECM interactions, toward the design of new regenerative therapies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18