Bonelike (R)/PLGA hybrid materials for bone regeneration: Preparation route and physicochemical characterisation

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Oliveira, JM (Author) Other; Miyazaki, T (Author) Other; Lopes, MA (Author) FEUP; Ohtsuki, C (Author) Other; Santos, JD (Author) FEUP

Journal

Title: Journal of Materials Science: Materials in Medicine

Vol. 16

Pages: 253-259

ISSN: 0957-4530

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 16 Citations

ISI Web of Science

Scopus - 20 Citations

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

CORDIS: Technological sciences > Engineering > Biomedical enginnering

Other information

Authenticus ID: P-000-4HV

DOI: 10.1007/s10856-005-6687-y

Abstract (EN): Bonelike(R)/PLGA hybrid materials have been developed using. gamma-MPS as silane-coupling agent between the inorganic and organic phases for controlled drug delivery applications. Silanization showed to be more effective when cyclohexane was used as a non-polar solvent (nP method) due to a chemical interaction between Bonelike(R) and the silane film, while by using a 95/5 (V/V) methanol/water as a polar solvent ( P method), a much thinner film was achieved. Functional groups of PLGA, such as the carbonyl group ( C = O), were identified using Raman and FTIR-ATR analysis and therefore these groups may be used to link therapeutic molecules. These novel hybrid materials prepared by combining silanization and post-hybridisation processes are expected to find use in medical applications of bone regeneration and as drug delivery carrier for therapeutic molecules. (C) 2005 Springer Science + Business Media, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7