Modelling neuromuscular blockade: a stochastic approach based on clinical data

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Conceicao Rocha (Author) Other; Teresa Mendonca (Author) FCUP; Maria Eduarda Silva (Author) FEP

Journal

Title: Mathematical and Computer Modelling of Dynamical Systems

Vol. 19 No. 6

Pages: 540-556

ISSN: 1387-3954

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 9 Citations

ISI Web of Science

Scopus - 11 Citations

Scientific classification

FOS: Natural sciences > Computer and information sciences

Other information

Authenticus ID: P-006-JG6

DOI: 10.1080/13873954.2013.801865

Abstract (EN): During surgical interventions, a muscle relaxant drug is frequently administered with the objective of inducing muscle paralysis. Clinical environment and patient safety issues lead to a huge variety of situations that must be taken into account requiring intensive simulation studies. Hence, population models are crucial for research and development in this field.This work develops a stochastic population model for the neuromuscular blockade (NMB) (muscle paralysis) level induced by atracurium based on a deterministic individual model already proposed in the literature. To achieve this goal, a joint Lognormal distribution is considered for the patient-dependent parameters. This study is based on clinical data collected during general anaesthesia. The procedure developed enables to construct a reliable reference bank of parametrized models that not only reproduces the overall features of the NMB, but also the inter-individual variability characteristic of physiological signals. It turns out that this bank constitutes a fundamental tool to support research on identification and control algorithms and is suitable to be integrated in clinical decision support systems.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17