Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Silva, V (Author) Other; Silva, C (Author) Other; Soares, P (Author) FCUP; Garrido, EM (Author) Other; Fernanda Borges (Author) FCUP; Garrido, J (Author) Other

Journal

Title: Molecules

Vol. 25

Final page: 991

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 64 Citations

Scopus - 83 Citations

Other information

Authenticus ID: P-00R-SSX

DOI: 10.3390/molecules25040991

Abstract (EN): The importance of isothiazole and of compounds containing the isothiazole nucleus has been growing over the last few years. Isothiazolinones are used in cosmetic and as chemical additives for occupational and industrial usage due to their bacteriostatic and fungiostatic activity. Despite their effectiveness as biocides, isothiazolinones are strong sensitizers, producing skin irritations and allergies and may pose ecotoxicological hazards. Therefore, their use is restricted by EU legislation. Considering the relevance and importance of isothiazolinone biocides, the present review describes the state-of-the-art knowledge regarding their synthesis, antibacterial components, toxicity (including structure-activity-toxicity relationships) outlines, and (photo)chemical stability. Due to the increasing prevalence and impact of isothiazolinones in consumer's health, analytical methods for the identification and determination of this type of biocides were also discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 22