The role of biomarkers in dilated cardiomyopathy: Assessment of clinical severity and reverse remodeling

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Amorim, S (Author) FMUP; Campelo, M (Author) FMUP; Moura, B (Author) Other; Martins, E (Author) FMUP; Rodrigues, J (Author) Other; Barroso, I (Author) Other; Faria, M (Author) Other; guimaraes, jt (Author) FMUP; Filipe Macedo (Author) FMUP; Silva Cardoso, J (Author) FMUP; Maciel MJ (Author) FMUP

Journal

Title: Revista Portuguesa de Cardiologia

Vol. 36

Pages: 709-716

ISSN: 0870-2551

Publisher: Sociedade Portuguesa De Cardiologia

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00N-BEB

DOI: 10.1016/j.repc.2017.02.015

Abstract (EN): Introduction: Biomarkers in dilated cardiomyopathy (DCM) reflect various pathobiological processes, including neurohormonal activation, oxidative stress, matrix remodeling, myocyte injury and myocyte stretch. We assessed the role of biomarkers in clinical and echocardiographic parameters and in left ventricular (LV) reverse remodeling (LVRR). Methods: In this prospective study of 50 DCM patients (28 men, aged 59 +/- 10 years) with LV ejection fraction (LVEF) <40%, LVRR was defined as an increase of >10 U in LVEF after optimal medical therapy. Results: Baseline LVEF was 25.4 +/- 9.8% and LV end-diastolic diameter (LVEDD)/body surface area (BSA) was 34.2 +/- 4.5 mm/m(2). LVRR occurred in 34% of patients within 17.6 +/- 15.6 months. No correlation was found between B-type natriuretic peptide (BNP), 25-hydroxyvitamin D (25(OH) D), CA-125, high-sensitivity C-reactive protein (hs-CRP), lipoprotein(a) [Lp(a)], noradrenaline, adrenaline, renin or aldosterone and LVRR. Patients in NYHA class III or IV, with pulmonary congestion or ankle edema, had higher CA-125, cystatin C, BNP and hs-CRP levels (p<0.05). CA-125 was correlated with BNP (r=0.61), hs-CRP (r=0.56) and uric acid (r=0.52) (all p=0.01). BNP correlated directly with LVEDD (r=0.49), LV volumes (r=0.51), pulmonary artery systolic pressure (PASP) (r=0.43) and E/e' (r=0.31), and was inversely correlated with LVEF (r=-0.50) and e' velocity (r=-0.32) (p<0.05). CA-125 was positively correlated with left atrial volume/BSA (r= 0.46), E/A ratio (r=0.60) and PASP (r=0.49) (p<0.05). Conclusions: No correlation was found between biomarkers and LVRR, but CA-125, BNP and hs-CRP were predictors of clinical severity and congestion. BNP correlated with parameters of systolic and diastolic dysfunction, while CA-125 correlated with measures of diastolic dysfunction.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8