Doping Polysulfone Membrane with Alpha-Tocopherol and Alpha-Lipoic Acid for Suppressing Oxidative Stress Induced by Hemodialysis Treatment

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Kohlova, M (Author) Other; Rocha, S (Author) Other; Amorim, CG (Author) FFUP; Araujo, AN (Author) FFUP; Alice Santos Silva (Author) FFUP; Solich, P (Author) Other; Montenegro, MCBSM (Author) FFUP

Journal

Title: Macromolecular Bioscience

Vol. 20

ISSN: 1616-5187

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-00S-A2N

DOI: 10.1002/mabi.202000046

Abstract (EN): The reduction of free radicals by bioactive membranes used for hemodialysis treatment is an important topic due to the constant rise of oxidative stress-associated cardiovascular mortality by hemodialysis patients. Therefore, it is urgent to find an effective solution that helps to solve this problem. Polysulfone membranes enriched with alpha-lipoic acid, alpha-tocopherol, and with both components are fabricated by spin coating. The antioxidant properties of these membranes are evaluated in vitro by determining the lipid-peroxidation level and the total antioxidant status of the blood plasma. The biocompatibility is assessed by quantifying the protein adsorption, platelet adhesion, complement activation, and hemolytic effect. All types of membranes show in vitro antioxidant activity and a trend to reduce oxidative stress in vivo; the best results show membranes prepared with a combination of both compounds and prove to be nonhemolytic and hemocompatible. Moreover, the membrane specific separation ability for the main waste products is not affected by antioxidants incorporation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14