3,4-Methylenedioxypyrovalerone (MDPV) Sensing Based on Electropolymerized Molecularly Imprinted Polymers on Silver Nanoparticles and Carboxylated Multi-Walled Carbon Nanotubes

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Couto, RAS (Author) Other; Coelho, C (Author) Other; Mounssef, B (Author) Other; Morais, SFD (Author) Other; Lima, CD (Author) Other; dos Santos, WTP (Author) Other; Felix Carvalho (Author) FFUP; Rodrigues, CMP (Author) Other; Braga, AAC (Author) Other; Goncalves, LM (Author) Other; M. Beatriz Q. Garcia (Author) FFUP

Journal

Title: Nanomaterials

Vol. 11

Pages: 1-18

ISSN: 2079-4991

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

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Other information

Authenticus ID: P-00T-E73

DOI: 10.3390/nano11020353

Abstract (EN): 3,4-methylenedioxypyrovalerone (MDPV) is a harmful and controlled synthetic cathinone used as a psychostimulant drug and as sport-enhancing substance. A sensor was developed for the direct analysis of MDPV by transducing its oxidation signal by means of an electropolymerized molecularly imprinted polymer (e-MIP) built in-situ on the screen-printed carbon electrode's (SPCE) surface previously covered with multi-walled carbon nanotubes (MWCNTs) and silver nanoparticles (AgNPs). Benzene-1,2-diamine was used as the functional monomer while the analyte was used as the template monomer. Each step of the sensor's development was studied by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) in a solution containing ferricyanide, however no redox probe was required for the actual MDPV measurements. The interaction between the poly(o-phenylenediamine) imprinted polymer and MDPV was studied by density-functional theory (DFT) methods. The SPCE-MWCNT-AgNP-MIP sensor responded adequately to the variation of MDPV concentration. It was shown that AgNPs enhanced the electrochemical signal by around a 3-fold factor. Making use of square-wave voltammetry (SWV) the developed sensor provided a limit of detection (LOD) of 1.8 mu mol L-1. The analytical performance of the proposed sensor paves the way to the development of a portable device for MDPV on-site sensing to be applied in forensic and doping analysis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18