Platinum(II) Ring-Fused Chlorins as Near-Infrared Emitting Oxygen Sensors and Photodynamic Agents

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Pereira, NAM (Author) Other; Laranjo, M (Author) Other; Casalta Lopes, J (Author) Other; Serra, AC (Author) Other; Pineiro, M (Author) Other; Pina, J (Author) Other; Sergio Seixas de Melo, JSS (Author) Other; Senge, MO (Author) Other; Filomena Botelho, MF (Author) Other; Martelo, L (Author) Other; Burrows, HD (Author) Other; Pinho e Melo, TMVDE (Author) Other

Journal

Title: Acs Medicinal Chemistry Letters

Vol. 8

Pages: 310-315

ISSN: 1948-5875

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 43 Citations

Scopus - 44 Citations

Other information

Authenticus ID: P-00M-HQC

DOI: 10.1021/acsmedchemlett.6b00476

Abstract (EN): Novel near-infrared luminescent compounds based on platinum(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins are described. These compounds have high photostability and display light emission, in particular simultaneous fluorescence and phosphorescence emission in solution at room temperature, in the biologically relevant 700-850 nm red and near -infrared (NIR) spectral region, making them excellent materials for biological imaging. The simultaneous presence of fluorescence and phosphorescence emission at room temperature, with the phosphorescence strongly quenched by oxygen whereas fluorescence remains unaffected, allows these compounds to be used as ratiometric oxygen sensors in chemical and biological media. Both steady-state (fluorescence vs phosphorescence intensities) oxygen concentration) luminescence approaches can be used. Photocytotoxicity studies against human melanocytic melanoma cells (A375) indicate that these compounds display potential as and dynamic (dependence of phosphorescence lifetimes upon hotocytotoxicity studies against human melanocytic melanoma photosensitizers in photodynamic therapy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6