Cytohistological Correlation in Pleural Effusions Based on the International System for Reporting Serous Fluid Cytopathology

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Pinto, D (Author) Other; Cruz, E (Author) Other; Branco, D (Author) Other; Linares, C (Author) Other; Carvalho, C (Author) Other; Silva, A (Author) Other; Chorao, M (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Diagnostics

Vol. 74

Publisher: MDPI

Indexing

ISI Web of Knowledge - 14 Citations

Other information

Authenticus ID: P-00V-4BE

DOI: 10.3390/diagnostics11061126

Abstract (EN): The International System for Reporting Serous Fluid Cytology (TIS) was recently developed. Given its novelty, most studies looking into the risk of malignancy (ROM) of serous effusion diagnostic categories were published before the development of TIS. We searched the database of our department for pleural effusions diagnosed in the last five years, excluding those without a corresponding pleural biopsy. Cases were reviewed and reclassified according to the TIS. A cytohistological correlation was performed. In total, 350 pleural effusion specimens with one or more corresponding pleural biopsies were included. After reclassification, 5 (1.43%) were nondiagnostic (ND), 253 (72.29%) were negative for malignancy (NFM), 7 (2.00%) had atypia of unknown significance (AUS), 14 (4.00%) were suspicious for malignancy (SFM), and 71 (20.57%) were malignant (MAL). Calculated ROM was 40% for ND, 20.16% for NFM, 42.86% for AUS, 78.57% for SFM, and 100% for MAL. Effusion cytology sensitivity and specificity were 60.29% and 98.56%, respectively. This is the first publication looking into the cytohistological correlation of a retrospective cohort of pleural effusions based on the TIS. We add to the body of data regarding the ROM for TIS categories, highlighting areas of potential future research.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12