Variants of Papillary Thyroid Carcinoma: An Algorithmic Cytomorphology-Based Approach to Cytology Specimens

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Canberk, S (Author) Other; Montezuma, D (Author) Other; Ince, U (Author) Other; Tastekin, E (Author) Other; Soares, P (Author) FMUP; Bongiovanni, M (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Acta Cytologica

Vol. 64

Pages: 288-298

ISSN: 0001-5547

Publisher: Karger

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-00R-8DV

DOI: 10.1159/000503576

Abstract (EN): Background:Thyroid cancer accounts for 1% of cancer cases in developed countries, in which papillary thyroid carcinoma (PTC) is the most common type. There are multiple variants of PTC described to date, some of them with aggressive behavior and poor clinical outcome. These variants are well described and accepted in recent guidelines of many international societies, and the prognostic and management implications are well laid out. Due to their established clinical importance and to guide appropriate surgical management, it is now imperative in clinical practice, including cytopathology, to differentiate aggressive variants from nonaggressive ones. This review aims to describe the variants of PTC and to provide a practical algorithmic approach to facilitate the cytological diagnosis of these variants.Summary:Subtyping PTC variants on fine needle aspiration cytology (FNAC) is challenging even for the most experienced cytopathologist. To facilitate a correct subtyping on FNAC, we propose a stepwise approach that is mainly designed for conventional smear methodology. This approach requires first to stratify the lesions into oncocytic and nononcocytic features before analyzing further details in cell morphology and pattern.Key Messages:(1) Subtyping in PTC is possible on cytopathology. (2) The main aim of the cytopathologist is to differentiate aggressive from nonaggressive variants. (3) The subtyping of PTC can help in the surgical management of the patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11