Cytopathology of Follicular Cell Nodules

• Type: Another Publication in an International Scientific Journal
• Date: 2017

Authors

Rossi, ED (Author) Other; Bizzarro, T (Author) Other; Martini, M (Author) Other; Larocca, LM (Author) Other; Fernando Schmitt (Author) FMUP; Vielh, P (Author) Other

Journal

Title: Advances in Anatomic Pathology

Vol. 24

Pages: 45-55

ISSN: 1072-4109

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-00M-D20

DOI: 10.1097/pap.0000000000000135

Abstract (EN): The detection of thyroid nodules, consisting of different diseases, represents a common finding in population. Their evaluation and diagnosis are mostly achieved with fine-needle aspiration cytology (FNAC). Even though the majority of thyroid nodules are correctly diagnosed, a total of 25% to 30% of them are classified "indeterminate" comprising lesions with varying risk of malignancy and different types of management. Although the number of thyroid FNACs, including small lesions, is increasing due to the reliance upon sonographic and cytologic interpretations, there are issues concerning cytomorphologic interpretation and interobserver reproducibility. Different classification systems have tried to better define the criteria for inclusion in specific categories and to therefore reduce the rate of indeterminate diagnoses such as atypia of undetermined significance, follicular neoplasms, and suspicious for malignancy. However, the support of ancillary techniques (eg, immunocytochemistry and molecular analysis) are reshaping morphologic diagnoses made on materials obtained from FNAC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11