Phyllodes tumours of the breast: A consensus review

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Tan, BY (Author) Other; Acs, G (Author) Other; Apple, SK (Author) Other; Badve, S (Author) Other; Bleiweiss, IJ (Author) Other; Brogi, E (Author) Other; Calvo, JP (Author) Other; Dabbs, DJ (Author) Other; Ellis, IO (Author) Other; Eusebi, V (Author) Other; Farshid, G (Author) Other; Fox, SB (Author) Other; Ichihara, S (Author) Other; Lakhani, SR (Author) Other; Rakha, EA (Author) Other; Reis Filho, JS (Author) Other; Richardson, AL (Author) Other; Sahin, A (Author) Other; Fernando Schmitt (Author) FMUP; Schnitt, SJ (Author) Other; Siziopikou, KP (Author) Other; Soares, FA (Author) Other; Tse, GM (Author) Other; Vincent Salomon, A (Author) Other; Tan, PH (Author) Other

Journal

Title: Histopathology

Vol. 68

Pages: 5-21

ISSN: 0309-0167

Publisher: Wiley-Blackwell

Indexing

Scopus - 304 Citations

Other information

Authenticus ID: P-00T-3S1

DOI: 10.1111/his.12876

Abstract (EN): Phyllodes tumours constitute an uncommon but complex group of mammary fibroepithelial lesions. Accurate and reproducible grading of these tumours has long been challenging, owing to the need to assess multiple stratified histological parameters, which may be weighted differently by individual pathologists. Distinction of benign phyllodes tumours from cellular fibroadenomas is fraught with difficulty, due to overlapping microscopic features. Similarly, separation of the malignant phyllodes tumour from spindle cell metaplastic carcinoma and primary breast sarcoma can be problematic. Phyllodes tumours are treated by surgical excision. However, there is no consensus on the definition of an appropriate surgical margin to ensure completeness of excision and reduction of recurrence risk. Interpretive subjectivity, overlapping histological diagnostic criteria, suboptimal correlation between histological classification and clinical behaviour and the lack of robust molecular predictors of outcome make further investigation of the pathogenesis of these fascinating tumours a matter of active research. This review consolidates the current understanding of their pathobiology and clinical behaviour, and includes proposals for a rational approach to the classification and management of phyllodes tumours. © 2016 John Wiley & Sons Ltd.

Language: English

Type (Professor's evaluation): Scientific