Metaplastic breast carcinomas are basal-like tumours

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Reis, JS (Author) Other; Milanezi, F (Author) Other; Steele, D (Author) Other; Savage, K (Author) Other; Simpson, PT (Author) Other; Nesland, JM (Author) Other; Pereira, EM (Author) Other; Lakhani, SR (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Histopathology

Vol. 49

Pages: 10-21

ISSN: 0309-0167

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 252 Citations

Scopus - 280 Citations

Other information

Authenticus ID: P-004-JTR

DOI: 10.1111/j.1365-2559.2006.02467.x

Abstract (EN): Aims: Recently, an immunohistochemical panel comprising antibodies against HER2, oestrogen receptor (ER), epidermal growth factor receptor (EGFR) and cytokeratin (CK) 5/6 was reported to identify basal-like breast carcinomas, as defined by cDNA microarrays. Our aim was to analyse a series of metaplastic breast carcinomas (MBCs) using this panel plus two other basal markers (CK14 and p63) and progesterone receptor (PR), to define how frequently MBCs show a basal-like immunophenotype. Methods and results: Sixty-five cases were retrieved from the pathology archives of the authors' institutions and reviewed by three of the authors. Immunohistochemistry with antibodies for HER2, ER, EGFR, CK5/6, CK14 and p63 was performed according to standard methods. All but six cases (91%) showed the typical immunoprofile of basal-like tumours (ER- and HER2-, EGFR+ and/or CK5/6+). When CK14 and p63 were added to the panel, two additional cases could be classified as basal-like. The majority of MBCs lacked PR, except 4/19 (21%) carcinomas with squamous metaplasia. Conclusions: Our results demonstrate that MBCs show a basal-like phenotype, regardless of the type of metaplastic elements. Moreover, as these neoplasms frequently overexpress EGFR (57%), patients with MBC may benefit from treatment with anti-EGFR drugs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12