Intradermal spindle cell/pleomorphic lipoma of the vulva: case report and review of the literature

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Reis, JS (Author) Other; Milanezi, F (Author) Other; Soares, MF (Author) Other; Fillus Neto, J (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Journal of Cutaneous Pathology

Vol. 29

Pages: 59-62

ISSN: 0303-6987

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 33 Citations

Scopus - 45 Citations

Other information

Authenticus ID: P-000-REP

DOI: 10.1034/j.1600-0560.2002.290112.x

Abstract (EN): Background: Spindle cell/pleomorphic lipoma (SC/PL) is a benign adipose tissue tumor that usually affects the subcutaneous tissues of shoulders, backs, and neck region of middle-aged male patients. Histologically, it is characterized by the presence of primitive CD34-positivc spindle cells arranged in short fascicles, bizarre floret-like multinucleated giant cells, mature adipocytes, and a small number of lipoblasts. Recently, air intradermal subset has been described, which mainly affects female patients and presents a wider antomical distribution when compared to the classical variant of SC/PL. Methods: We report a case, of intradermal SC/PL affecting the labium majus of a 56-year-old female patient. Results: The histological examination disclosed the typical histological features, however the lesion showed poorly demarcated and infiltrative borders, as well as involvement of dermal nerves. The immunohistochemical analysis according to streptovidin-biotin-peroxidase technique showed immunoreactivity for CD34 and vimentin in the spindle cells, as well as S100 protein and vimentin in the adipocytic cells. Conclusions: To the best of our knowledge, this is the first case of intradermal SC/PL affecting the vulvar region. Care must be taken not to misdiagnosis this rare tumor as well-differentiated liposarcoma, cellular angiofibroma, solitary fibrous tumor, and cutaneous neurofibroma.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4