Primary epithelial malignant mesothelioma of the pericardium with deciduoid features: Cytohistologic and immunohistochemical study

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Reis, JS (Author) Other; Pope, LZB (Author) Other; Milanezi, F (Author) Other; Balderrama, CMSR (Author) Other; Serapiao, MJ (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Diagnostic Cytopathology

Vol. 26

Pages: 117-122

ISSN: 8755-1039

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 26 Citations

Other information

Authenticus ID: P-000-QD2

DOI: 10.1002/dc.10068

Abstract (EN): Malignant mesothelioma with deciduoid features (MMWDF) is a recently characterized morphologic variant of epithelioid malignant mesothelioma, which frequently is misdiagnosed as peritoneal deciduosis or florid mesothelial hyperplasia. We report oil the cytological, histological, immunohistochemical, and autopsy findings of a case of MMWDF arising in the pericardium of a 71-yr-old female patient. Cytology showed large, polygonal to round cells with pale to bright, eosinophilic cytoplasm, occasionally showing xantomatous pattern, containing a pleomorphic and vesicular nucleus with a single prominent nucleolus. Autopsy examination showed a neoplasm encasing the heart and great vessels. No other primary, neoplasm was found. The histological analysis disclosed the typical features of MMWDF. Immunohistochemistry showed diffuse immunoreactivity for cytokeratin MNF116, HBME-1, and calretinin in the neoplastic cells, as well as focal positivity for epithelial membrane antigen positivity in a brush border-like pattern. All other markers were negative. We would like to stress that pathologists must be aware of the cytological and histological features of this rare variant of epithelioid malignant mesothelioma in order to avoid a misdiagnosis of a benign process or a metastatic malignancy. Diagn. Cytopathol. 2002 26:117-122; DOI 10.1002/dc.10068 (C) 2002 Wiley-Liss, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6