Locally advanced cancer of the breast (LACB) and identification of estrogen receptors with monoclonal antibodies [Considerações sobre o câncer localmente avançado de mama (CLAM) acrescidas de identificação dos receptores de estrogênios usando anticorpos monoclonais.]

• Type: Another Publication in an International Scientific Journal
• Date: 1993

Authors

de Luca, LA (Author) Other; Fernando Schmitt (Author) Other; Traiman, P (Author) Other; Oliveira Junior, B (Author) Other; de Andrade, LM (Author) Other; Rudge, MV (Author) Other; Lunardi, MT (Author) Other

Journal

Title: Revista da Associacao Medica Brasileira

Vol. 39

Pages: 17-32

ISSN: 0104-4230

Publisher: Elsevier

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-008-PRA

Abstract (EN): The effects of therapy in locally advanced breast cancer submitted to combined conventional telecobalt therapy plus chemotherapy with cyclophosphamide and 5-fluorouracil were studied in 49 patients. Associated to radical mastectomy in operable cases. Local tumor control was achieved in 86.7%. There were no local recurrences in those submitted to surgery but they reached 21.7% in inoperable patients who received only radiation therapy and chemotherapy. The median follow-up time for dead patients was 29.5 months and for living patients 79.3 months. The index of complete responses was 24.5% and the median disease free interval was 22.9 months. The overall survival rate, between three and five years, was 32.7%. Estrogen receptors were identified by using immunohistochemical assay ER-ICA and monoclonal antibody H222-SP gamma, Abbott. There were no differences in the complete response index, disease free interval and survival rates, among ER-positive and ER-negative patients, explained by the far advanced stage of the disease. ER-positivity was significantly correlated with histological features of the tumors: cell differentiation, presence of elastosis, absence of lymphocytic infiltration and absence of tumor necrosis.

Language: Portuguese

Type (Professor's evaluation): Scientific