The diagnostic and prognostic role of liquid-based cytology: are we ready to monitor therapy and resistance?

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Rossi, ED (Author) Other; Bizzarro, T (Author) Other; Longatto, A (Author) Other; Gerhard, R (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Expert Review of Anticancer Therapy

Vol. 15

Pages: 911-921

ISSN: 1473-7140

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 20 Citations

Other information

Authenticus ID: P-00G-EKZ

DOI: 10.1586/14737140.2015.1053874

Abstract (EN): Here, we evaluate the diagnostic and prognostic role of liquid-based cytology (LBC) in different body lesions, including thyroid, lung, effusions and malignant breast lesions. LBC has gained consensus after being applied to both non-gynecologic and fine-needle aspiration cytology. Although some remain sceptical regarding the diagnostic efficacy of LBC, mainly when used alone, in recent years, good results have been obtained as long as it showed a high diagnostic accuracy. Here, we discuss the additional possibility of storing material for the application of ancillary techniques (immunocytochemistry-molecular analysis) with several diagnostic and prognostic advantages, which may pave the way for the challenging evaluation of both monitoring responses to treatment and resistance to targeted therapies in thyroid, lung, breast carcinoma or malignant effusions. Furthermore, it provides the use of several molecular spots as specific targets for personalized therapy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11