CD26 (dipeptidyl aminopeptidase IV) expression in normal and diseased human thyroid glands

• Type: Article in International Scientific Journal
• Date: 1998

Authors

Lima, MA (Author) Other; Gontijo, VA (Author) Other; Fernando Schmitt (Author) Other

Journal

Title: Endocrine Pathology

Vol. 9

Pages: 43-52

ISSN: 1046-3976

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-001-8B5

DOI: 10.1007/bf02739951

Abstract (EN): The objective of the present study was to investigate CD26 (dipeptidyl aminopeptidase IV) expression in normal and diseased thyroids and its relation to differentiation and cell proliferation. CD 26 was also evaluated as a possible marker of malignancy in thyroid neoplasias. A total of 38 normal thyroids and 117 diseased thyroids (neoplastic and non-neoplastic) were evaluated. CD26 and thyroglobulin (Tg) expression was determined by analyzing at least 200 cells/specimen. A minimum of 500 cells/specimen were counted to calculate the MIB-1-positive cell rate expressed as a percentage of total nucleated epithelial cells. CD26 expression was absent in all thyroids from fetuses and children. Among the adults, 7.1% had CD26 expression only in oncocytic metaplastic areas. In 3 of the 7 elderly subjects, CD26 expression was present in 0.2-90% of epithelial cells. CD26 expression was observed in all diseased thyroids. Since this enzyme is also expressed in benign conditions, it is not useful as a marker of malignancy. There was no relationship between CD26 and Tg expression. The MIB-1-positive cell rate was found to be low for all kinds of thyroid tissues, and when the cell proliferation rate was analyzed according to CD26 expression, a greater cell proliferation rate was found in CD26-positive differentiated (follicular and papillary) carcinomas than in CD26-negative carcinomas. These results demonstrate that expression of this enzyme is related to the proliferative activity of follicular cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10