P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Joana Paredes (Author) Other; Stove, C (Author) Other; Stove, V (Author) Other; Milanezi, F (Author) Other; Van Marck, V (Author) Other; Derycke, L (Author) Other; Mareel, M (Author) Other; Bracke, M (Author) Other; Fernando Schmitt (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: CANCER RESEARCH

Vol. 64

Pages: 8309-8317

ISSN: 0008-5472

Indexing

ISI Web of Knowledge - 60 Citations

Scopus - 62 Citations

Other information

Authenticus ID: P-000-7QJ

DOI: 10.1158/0008-5472.can-04-0795

Abstract (EN): P-cadherin expression in breast carcinomas has been associated with tumors of high histologic grade and lacking estrogen receptor-alpha, suggesting a link between these proteins. In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-alpha signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9