P-cadherin expression in glandular lesions of the uterine cervix detected by liquid-based cytology

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Longatto Filho, A (Author) Other; Albergaria, A (Author) Other; Joana Paredes (Author) Other; Moreira, MAR (Author) Other; Milanezi, F (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Cytopathology

Vol. 16

Pages: 88-93

ISSN: 0956-5507

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-000-3YV

DOI: 10.1111/j.1365-2303.2004.00226.x

Abstract (EN): Objective: To study P-cadherin aberrant expression as a possible marker for cervical adenocarcinomas in cytological samples. Methods: We studied P-cadherin immunoexpression in liquid-based cervical cytology samples of biopsy-proven cervical lesions. Results: We found a statistically significant correlation between P-cadherin expression and a cytological diagnosis of malignancy, either glandular or squamous (P < 0.0001). Twenty-two of 33 malignant cases showed P-cadherin membrane staining. None of the 30 benign cases tested showed membrane staining, but three of them displayed an aberrant nuclear P-cadherin expression. Conclusions: We concluded that P-cadherin can be used to discriminate between malignant and benign cervical cytological specimens, but not to discriminate glandular from squamous lesions.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6