P-cadherin expression in canine mammary tissues

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Gama, A (Author) Other; Joana Paredes (Author) Other; Albergaria, A (Author) Other; Gartner, R (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Journal of Comparative Pathology

Vol. 130

Pages: 13-20

ISSN: 0021-9975

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 25 Citations

Other information

Authenticus ID: P-000-D1N

DOI: 10.1016/s0021-9975(03)00064-1

Abstract (EN): P-cadherin is a classical cadherin expressed by myoepithelial cells in mammary tissue. Its expression in human breast cancer has been associated with aggressive tumour behaviour. To analyse the possible role of P-cadherin in canine mammary carcinogenesis, its expression was examined immunohistochemically in 82 samples of normal (n = 2), hyperplastic (n = 11) and neoplastic (n = 69) canine mammary tissues. In normal and hyperplastic canine mammary glands, P-cadherin was restricted to myoepithelial cells, usually, at sites of cell-to-cell contact. In tumour tissues, however, P-cadherin expression was observed in both epithelial and myoepithelial cells, with a cytoplasmic pattern of cellular distribution. Aberrant epithelial P-cadherin immunolabelling was found in 19/44 (43%) benign tumours and in 16/25 (64%) malignant tumours (P < 0.001). In malignant tumours, a significant correlation between P-cadherin expression intensity and histological type was observed (P < 0.05).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8