Taking advantage of basic research: p63 is a reliable myoepithelial and stem cell marker

• Type: Another Publication in an International Scientific Journal
• Date: 2002

Authors

Reis, JS (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Advances in Anatomic Pathology

Vol. 9

Pages: 280-283

ISSN: 1072-4109

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 86 Citations

Other information

Authenticus ID: P-000-N19

DOI: 10.1097/00125480-200209000-00002

Abstract (EN): p63 is a recently characterized p53-homolog that is consistently expressed by basal/somatic stem cells of stratified epithelia, myoepithelial cells of the breast and salivary glands, and proliferative compartment of gastric mucosa. p63 is located on the long arm of chromosome 3 (3q27) and it encodes six isoforms, three transactivating (TA) and three DeltaN-isoforms. While the first three isoforms may act as tumor suppressor genes, the DeltaN-isoforms may inhibit the p53/TA-p63-driven cell cycle arrest and apoptosis. Recently, the putative applications of p63 in the identification of myoepithelial cells of the breast and basal cells of the prostate acini have been evaluated however, no critical systematic analysis of its role in surgical pathology practice have hitherto been reported. We review the putative roles of p63 in surgical pathology practice and provide guidelines for future directions on p63 translational research.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4